1R21DK071023-01 4/1/05-03/31/08.(注:世界上第一个转基因干细胞治疗项目) Cytokine-modified stem cells in kidney transplantation. 首席科学家: 陈思锋
10. 国家自然科学基金面上项目:1993.1-1994.12🤜🏿,维生素D3和维甲酸降低血管通透性的机制,(39270789),负责人:陈思锋
11. 国家自然科学基金面上项目:1995.1-1997.12,全身炎症时内皮细胞内维生素D3受体的变化及其调节,39470679 负责人:陈思锋
12. 国家自然科学基金面上项目:1997.1-1999.12,血管扩张时血管内皮细胞结构和功能的变化, 3960006,负责人:陈思锋
13. NIH/NIDDK R21 DK067472-016/1/04-5/31/06.AAV type 1 and 5 vectors for gene delivery in the kidney. PI: Agarwal; Co-Investigator:陈思锋
14. NIH/NIDDK R01 DK59600 6/1/04-5/31/06, Human heme oxygenase-1 gene regulation in renal injury. Principal Investigator: Agarwal; Co-Investigator:陈思锋
15. 国际I型糖尿病协会重大项目1/1/2001–12/31/2005 Principal Investigator: Mark A. Atkinson: “The JDFI Gene Therapy Center for the Prevention of Diabetes and Diabetic Complications at the University of Florida and the University of Miami”; Project 3: PI-Agarwal,Co-Investigator:陈思锋. K1-K3 angiostatin gene therapy for prevention of vascular endothelial cell proliferation and renal transplant loss.
16. NIH/NIDDK R01 07/01/2006-06/30/2011.Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection. Principal Investigator: Agarwal; Co-Investigator:陈思锋
课程讲授:
本科生课程:
病理生理学🟠、Pathophysiology、医疗保险经济学
研究生课程:
高级病理生理学𓀔、人体病理生理学、实用生物医学技术
学术兼职(目前在任期内的):
1. 中国生理协会副理事长兼继续教育委员会主任委员和循环专业委员会副主任委员
2. 中国病理生理协会常务理事兼微循环专业委员会副主任委员
3. 中国微循环协会常务理事
4. 上海生理科学会理事长
5. 上海病理生理协会副理事长
代表性论著:
1. Yansong Ren, Jinbo Liu, Huijun Xu, Shun Wang, Shirui Li, Meng Xiang, and Sifeng Chen*. Knockout of integrin β1 in induced pluripotent stem cells accelerates skin-wound healing by promoting cell migration in extracellular matrix. Stem cell research & therapy. Accepted.
2. Wang, X., Lu, M., Tian, X., Ren, Y., Li, Y., Xiang, M., and Chen, S.(2020). Diminished expression of major histocompatibility complex facilitates the use of human induced pluripotent stem cells in monkey. Stem cell research & therapy 2020 Aug 3; 11(1):334. doi: 10.1186/s13287-020-01847-9.
3. Meng Lu#; Rong Xue#; Pingping Wang; Xiaokai Wang; Xiaoyu Tian; Yingying Liu; Shun Wang; Anfeng Cui; Jingxin Xie; Lili Le; Meng Zhao; Jing Quan; Ning Li; Dan Meng; Xinhong Wang; Ning Sun; Alex F. Chen; Meng Xiang*; Sifeng Chen*; Induced pluripotent stem cells attenuate chronic allogeneic vasculopathy in an integrin beta-1-dependent manner. American Journal of Transplantation. Am J Transplant. 2020 Oct;20(10):2755-2767.
4, 陈思锋.2019新型冠状病毒导致的致命肺渗漏的病理生理学机制和防治策略:兼论血透的应用与依据.《中国病理生理杂志》 2020,Vol.36(3): 562-567.DOI: 10.3969/j.issn.1000-4718.2020.03.028
5. Meng Lu , Peng Lu , Ming Xu, Xiaokai Wang , Anfeng Cui , Yijun Li , Xinhong Wang , Dan Meng , Ning Sun , Meng Xiang, and Sifeng Chen. Enhanced wound healing promotion by immune response-free monkey autologous iPSCs and exosomes vs. their allogeneic counterparts. EBioMedicine. 2019 Apr;42:443-457.
6. Ruiting Sun, Yingying Liu, Meng Lu, Qianqian Ding, Pingping Wang, Heng Zhang, Xiaoyu Tian, Peng Lu, Dan Meng, Ning Sun, Meng Xiang, Sifeng Chen. ALIX Increases Protein Content and Protective Function of iPSC-derived Exosomes. J Mol Med (Berl). 2019 Jun;97(6):829-844.
7. Xiang M, Lu M, Quan J, Xu M, Meng D, Cui A, Li N, Liu Y, Lu P, Kang X, Wang X, Sun N, Zhao M, Liang Q, Le L, Wang X, Zhang J, Chen S. Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Theranostics. 2019 Jan 1;9(1):290-310. doi: 10.7150/thno.28671.
8. Chen B, Kapturczak MH, Joseph R, George JF, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Tisher CC, Flotte TR, Agarwal A, Chen S. Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model. American journal of transplantation. 2007;7:1112-1120
9. Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz PE, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:7251-7256
10. Chen S, Agarwal A, Glushakova OY, Jorgensen MS, Salgar SK, Poirier A, Flotte TR, Croker BP, Madsen KM, Atkinson MA, Hauswirth WW, Berns KI, Tisher CC. Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. Journal of the American Society of Nephrology : JASN. 2003;14:947-958.